Waters Acquity UPLC with Xevo QToF Mass Spec

Ultra High Performance Liquid Chromatography - Mass Spectrometry System 2 (UPLC-QToF MS)

Ultra High Performance Liquid Chromatography System (UPLC) is a technique used to separate, identify, and quantify specific components in mixtures. A Quadrupole Time-of-Flight (QToF) mass spectrometer combines the ion selection properties of a quadrupole with the high mass resolution and accuracy of a ToF in a single system. The mass to charge ratio (m/z) of an ion are determined by measuring the time of flight of the accelerated ions by an electric field of known strength in a known distance. The heavier ions travel slower than the lighter ions.

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Detailed Description

QToF is a high-resolution mass spectrometer with the ability to measure accurate mass to charge ratios (m/z) with four decimal places providing unparalleled substance identification. The ability to perform MS/MS analysis in which the quadrupole selects a specific precursor ion which is then fragmented in a collision cell and the fragments detected in the ToF allow structural identification to be performed. The QToF is connected to a quaternary liquid chromatography system enabling both isocratic and gradient elution or a Waters UPC2 SFC system for the separation of complex mixtures prior to mass spectrometry.

• Waters Xevo G2-XS QToF
• Mass range: 20-100,000 m/z
• Positive and negative detection modes
• Mass accuracy: 1ppm with up to
40,000 FWHM mass resolution
• ACQUITY LC system with flow rate:
0.01 to 2mL in 0.001mL increments
• 96 x 2mL vials